Objective - To assess vaccination coverage against diphtheria, tetanus, polio, and influenza among an adult population of pilgrims traveling to Mecca. Method - During vaccination against meningococcal meningitis A, C, Y, and W135 of 721 patients at the Strasbourg International Vaccination Center, the dates of their last booster vaccination against diphtheria, tetanus, polio, and influenza were recorded. A vaccination was considered up to date if it was administered within the past 10 years, except for the influenza vaccine, which had to be administered within the past year. Results - Of the 721 pilgrims traveling to Mecca aged 21 to 85 years (mean 53 years), 34% were up to date on their tetanus vaccination; 25% for polio; 22% for diphtheria; and 11% for influenza. There was no significant difference between the sexes, but vaccination coverage for diphtheria, tetanus, and polio decreased significantly (p < 0.0001) with age. For the age groups 21–30, 31–50, 51–70, and 71 and older, 56%, 22%, 19%, and 7% are up to date for diphtheria; 63%, 28%, 34%, and 16% for tetanus; and 56%, 24%, 24%, and 11% for polio. Conclusion - Pilgrims traveling to Mecca constitute a specific group of travelers with unsatisfactory vaccination coverage. Information for these individuals and their physicians regarding official recommendations must be widely disseminated prior to the vaccination campaign against meningitis using the quadrivalent vaccine. (R.A.)