A feasibility study on the screening for fetal alcohol syndrome (FAS) at birth was conducted over a two-year period in French regions and departments covered by registries of congenital malformations or childhood disabilities. Cases were included if they presented with intrauterine growth restriction involving weight, height, or head circumference, as well as dysmorphic features characteristic of FAS. Alcohol consumption was assessed using a dietary questionnaire. A total of 34 cases were included, of which 21 were classified as FAS at birth, but only 12 cases were considered confirmed FAS following a nine-month follow-up. All confirmed cases were included in Alsace and the Rhône. The calculated prevalence rates vary from one department to another and from one study year to another, suggesting significant underreporting, which is highly operator-dependent. (R.A.)