Introduction: This article describes the perceptions and practices regarding hepatitis B vaccination among private general practitioners in metropolitan France. Methods: A random sample of 1,582 general practitioners practicing in metropolitan France was surveyed by telephone between April and July 2014. Results: The majority of physicians surveyed (90.3%) reported having been fully vaccinated against hepatitis B. Three-quarters of physicians who were parents of children aged 2 to 24 reported that their child(ren) were fully vaccinated against hepatitis B. For 16.6%, none of their children were vaccinated. Half of the general practitioners believed it was easy to get unvaccinated adolescents to agree to this vaccination. The link between the hepatitis B vaccine and multiple sclerosis was considered "not at all likely" by 48.0% of the doctors and "unlikely" by 40.3%. One-third of doctors (34.0%) routinely offered the hepatitis B vaccine to adolescents. One in 10 “never” offered it. Half of the doctors surveyed (51.9%) stated that they “always” explained the diseases targeted by the hexavalent vaccine when offering it; one in five doctors stated they did so “sometimes” or “never.” Conclusion: while the majority of doctors are confident in the safety of the hepatitis B vaccine, they perceive their patients as reluctant toward this vaccination. Providing doctors with the necessary arguments to facilitate uptake of this vaccination thus appears essential.