Objectives. Tularemia has been included on the list of notifiable diseases (ND) since 2002 as part of the plan for the prevention of nuclear, radiological, biological, and chemical risks, in order to promptly detect potential infections of malicious origin and to monitor trends in naturally occurring disease. We report the results of 10 years of national surveillance. Materials and Methods. A case is defined by a suggestive clinical presentation combined with biological confirmation. The notification form collects clinical, biological, and epidemiological information. If no plausible risk exposure is mentioned on the form, a supplementary questionnaire is submitted to the physician and the patient. Results. From 2002 to 2012, 433 cases were reported, with a median age of 49 years (range 2–95 years) and a male-to-female ratio of 1.83. The highest incidence was recorded in Poitou-Charentes. The most common clinical presentations were lymphadenopathic (n=200; 46%) and ulcerative-lymphadenopathic (n=113; 26%). The most common risk exposures were handling hares (n=179; 41%) and leisure activities involving exposure to aerosols (n=217; 50%). Eighty-two patients (19%) reported tick bites. Ten clusters (39 cases) were detected, and a national outbreak occurred during the winter of 2007/2008. Conclusions. Surveillance for tularemia has demonstrated its ability to detect clusters and outbreaks. The collected data indicate that recreational activities involving aerosol exposure are the primary source of infection in France. (R.A.)