In 2008, the number of reported cases of active tuberculosis was 5,758, or 9.0 per 105 inhabitants. The median age of cases was 45 years, and 59% of reported cases were men. In 2008, Île-de-France and French Guiana remained the regions with the highest reporting rates (17.9 per 105 and 22.6 per 105, respectively). The reporting rate was higher among people born abroad (43.2 per 105 vs. 5.0 per 105 among people born in France) and particularly among those who had recently arrived in France. Pulmonary tuberculosis accounted for 72% of reported cases, and among these cases, 76% were potentially contagious (positive direct examination or culture). Compared to 2007, the number of cases increased by 3.3% in 2008. This increase was not accompanied by a rise in the number of severe cases (meningitis, miliary tuberculosis) and appeared to be partly linked to improved case detection and reporting. This trend, however, calls for vigilance in the coming years. A national tuberculosis control plan was launched in 2007 to reduce the epidemiological disparities that continue to exist. Maintaining sufficient clinical and public health expertise throughout the country is necessary for the measures implemented to ultimately have the expected impact on the epidemiology of the disease. (R.A.)