Objective - To evaluate the use of the TB-Info® software and its role in improving knowledge and management of tuberculosis cases. Method - Cohort study: patients followed in 2 hospitals in the Ile-de-France region and in 5 medical-social centers in the City of Paris using the TB-Info® software, who were placed on anti-tuberculosis treatment (ATT) during 2004. Results - 209 courses of anti-tuberculosis treatment (ATT) were initiated in 2004, with an average duration of 7.2 months. The epidemiological and clinical characteristics reflect the precarious situation of the study population. Screening for viral co-infections was performed in over 80% of cases. In this cohort, 21 patients were lost to follow-up (10.2%). The success rate for pulmonary forms with positive direct microscopy was 76.2%, but only 33.8% of cases were confirmed as cured by end-of-treatment samples. Conclusion - Analysis of data from the TB-info software shows an improvement in clinical practices: screening for co-infections, and a decrease in the number of patients lost to follow-up. However, analysis of treatment outcomes reveals a gap between current results and international targets. These results confirm the value of the software tool for patient follow-up and the evaluation of professional practices in France. (R.A.)