Introduction: Tetanus, a severe acute toxic infection that is often fatal, can be prevented through vaccination. Cases reported in France between 2012 and 2017 are presented here. Methods: In France, only cases of generalized tetanus are subject to mandatory reporting (MR) and must be reported by physicians to the Regional Health Agencies. Results: Between 2012 and 2017, a total of 35 cases of tetanus were reported, of which 8 resulted in death, representing a case-fatality rate of 23%. The distribution of cases is as follows: 5 in 2012, 10 in 2013, 3 in 2014, 9 in 2015, 4 in 2016, and 4 in 2017, corresponding to an incidence of reported cases ranging from 0.05 to 0.15 cases per million inhabitants. The cases mainly involve older adults (71% were 70 years of age or older) and women (63%). Although tetanus vaccination has been mandatory in France before the age of 18 months since 1940, 3 cases were under 10 years of age. The annual incidence by sex ranges from 0.03 to 0.21 cases per million for women and from 0.03 to 0.10 cases for men. Regarding the route of entry, these were injuries (77% of cases) and chronic wounds (20%). In 3% of cases, the route of entry was not identified. All cases for which vaccination status could be documented were unvaccinated or inadequately vaccinated. Discussion: All of these cases and deaths could have been prevented through better adherence to the tetanus vaccination schedule and, in the event of a wound, through vaccination and the administration of specific human immunoglobulins according to the recommended protocol.