Empowering current and future generations to develop their ability to make informed and reasoned choices, their skills in living together, and their capacity to better manage stress and regulate their emotions by strengthening their psychosocial skills (PSS) is a key driver of health promotion. Over the past thirty years, numerous research studies have demonstrated the importance of PSRs in children’s development, well-being, and health, starting from a very young age. In France today, several public policies reference PSRs: six national public health plans (priority prevention, mental health and psychiatry, addictions, tobacco, sexual health, cancer), the educational health pathway, and the Ministry of National Education’s “Health-Promoting School” initiative, within higher education and agricultural education, and at the regional level (Regional Health Agencies, local authorities, local health contracts, etc.). A national multisectoral strategy for developing HPS in children and young people is currently being rolled out. This document, intended for decision-makers and practitioners, reviews the scientific knowledge on HPS and provides initial guidelines for action and decision-making. Developed by Santé publique France in collaboration with several researchers, practitioners, and decision-makers, it is organized into eight chapters.-Chapter 1 offers an updated definition and categorization based on the scientific literature and international classifications (WHO, CASEL, OECD, etc.).-Chapter 2 describes each of the 9 general SEL competencies (and 21 specific competencies) identified: 3 cognitive competencies (self-awareness, self-management, constructive decision-making), 3 emotional competencies (awareness of one’s emotions and stress, regulation of one’s emotions, stress management), 3 social CPS (constructive communication, constructive relationships, problem-solving).-Chapter 3 reviews the history of CPS programs in France.-Chapter 4 discusses the inclusion of CPS in public policy.-Chapter 5 presents the use of CPS programs across regions. -Chapter 6 provides an overview of the effects of evidence-based CPS programs on health (reduction in addiction, violence, mental health and sexual health issues, increased well-being) and educational success (improved school climate, academic performance, and employment outcomes).-Chapter 7, drawing on effectiveness and implementation studies, presents the “key factors” common to various evidence-based CPS programs (2 main factors and 6 complementary factors) to facilitate the development of high-quality CPS interventions.-Chapter 8 outlines general principles, as well as the types and stages of CPS intervention evaluation. This report and its summary (available on the Santé publique France website) constitute a theoretical reference framework; they will be supplemented later by more practical, operational guides and resources.They contribute to fostering a shared vision of CPS, with the aim of taking early action throughout a child’s development and in all settings, toward a generational goal of ensuring that a new generation benefits from CPS development throughout their life course.