Introduction. An epidemiological surveillance network for periarticular disorders and their risk factors in the workplace has been in place in the Pays de la Loire region since 2002. This report focuses solely on data concerning workplace stress factors. Methods. In 2002, the epidemiological surveillance included 1,495 employees (895 men, 600 women) representative of the region’s workforce. The three psychosocial dimensions of Karasek’s “demand-autonomy” model (psychological demand, decision latitude, and social support at work) were assessed using Karasek’s Job Content Questionnaire prior to the occupational health consultation. Results. Approximately 17% of employees are exposed to high psychological demand while having low decision latitude to cope with it. Situations of "workplace strain" combining high psychological demand and low decision-making latitude—whether or not associated with social isolation—are particularly common, on the one hand, in highly Taylorized industries (food processing, automotive) and, on the other hand, in service sectors characterized by very strong market constraints, such as retail and business services. Discussion. The study confirms that exposure to occupational stress is not limited to managers but affects a large number of public servants and employees and workers in the private sector. Indeed, while highly skilled professions are characterized by high psychological demands, individuals in these roles have significant decision-making autonomy that allows them to develop their capabilities. Low-skilled occupations generally face lower psychological demands than managers. However, unlike managers, individuals often lack sufficient decision-making autonomy to cope with these demands, which leads to significant psychological strain, particularly when social support from the work group and management is weak. Conclusion. The study confirms, in a representative sample of the working population, the frequency of exposure to psychosocial stress in the workplace, regardless of socio-professional category. The determinants of stress vary by category, a fact that should be taken into account by workplace stress prevention programs.