Vaccination against invasive meningococcal C infections in Dieppe, Seine-Maritime. Assessment of vaccination coverage among individuals aged 1 to 19 years during the MenBvac® vaccination campaign, October 2008–June 2009. Final Report

Since 2003, Seine-Maritime has been the site of a significant number of invasive meningococcal infections (IMI), particularly of serogroup B. Dieppe and its surrounding municipalities have been particularly affected. Since July 2006, a vaccination campaign using the MenBvac® vaccine has been implemented in this area, which comprises six cantons. The department has seen an increase in the incidence of IIM C over three years, although this has not affected Dieppe. We conducted a survey to assess meningococcal C vaccination coverage in the Dieppe area among individuals aged 1 to 19 years eligible for vaccination with MenBvac®. A cross-sectional study was conducted between October 2008 and June 2009 at MenBvac® vaccination sites. Children were selected at each vaccination site using systematic stratified sampling across four age categories. Anonymous data were collected via a structured questionnaire that included not only vaccination and demographic data collected by the vaccinator at the site but also socioeconomic data provided by the parents. A total of 718 children were included, of whom 187 were vaccinated, resulting in an adjusted meningococcal C vaccination coverage of 22.3% (95% CI: 19.6%–25.3%). This coverage was higher among younger children (p<0.01) and among children who had received at least one dose of MenBvac® (p<0.01). Financial difficulties were cited as a frequent reason (19%) for non-vaccination, and 24% of the families of vaccinated children had encountered financial difficulties in vaccinating their child. Although the vaccination coverage rates estimated by this study were relatively high for a vaccine that was neither recommended nor reimbursed at the time of the survey, they remained insufficient to conclude that the population’s level of immunity could have interrupted the circulation of meningococcal C strains in Dieppe. Economic factors are very likely a significant factor in the decision to vaccinate a child. These data should be interpreted with caution due to the study’s limitations, particularly the absence of a reference population. (R.A.)

Author(s): Guthmann JP, Levy Bruhl D, Parent du Chatelet I

Publishing year: 2010

Pages: 15 p.

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