Objectives: To describe, over a two-year period, an outbreak of Staphylococcus aureus skin infections carrying genes encoding Panton-Valentine leukocidin (S. aureus PVL+) in a school setting. The prevalence of nasal colonization was estimated in families where new skin infections occurred despite control and prevention measures. Patients and methods: In October 2006, following a report of Sa PVL(+) abscesses and boils in an elementary school, a retrospective investigation of skin infections suggestive of Sa was conducted, along with surveillance and treatment of new infections occurring among students and their family members. Following an initial systematic screening for Sa PVL(+) nasal colonization, additional screenings were conducted in families where new skin infections occurred. Results: As of October 31, 2008, 53 individuals across 30 families had developed 69 skin infections in four successive waves of decreasing magnitude. The cumulative incidence of a first skin infection was 34.6% in elementary school, 21.3% in preschool, and 6.5% among the students’ family members. Multiple cases were reported in 13 families, with all seven members of one household developing one or more skin infections during follow-up. The prevalence of nasal colonization ranged from 14.1% to 19.5% during successive screenings. Conclusion: Early reporting of clusters of PVL-positive cutaneous infections is necessary to enhance the effectiveness of hygiene and prevention measures and thereby limit the risk of the outbreak persisting.