Introduction - Strokes have multiple causes that affect patients’ functional and overall prognosis. Our objective was to measure and compare 28-day mortality associated with strokes according to etiology and sex in a sample of the general French population. Methods - Data were obtained from the Lille Stroke Registry, which collects all stroke cases among residents aged 35 years and older. All cases recorded between 2008 and 2017 were included in this study. Mortality was recorded at 28 days. Results - Of 2,933 strokes, hemorrhagic and ischemic strokes accounted for 16% and 84% of cases, respectively, and mortality rates were 48% and 15%. The majority of deaths (75%) occurred within 6 days after a hemorrhagic stroke and within 16.5 days after an ischemic stroke. Mortality rates did not differ by sex after a hemorrhagic stroke, but were higher in women than in men (18% vs. 12%, respectively) after an ischemic stroke. This difference disappeared after adjusting for age. Among ischemic strokes, cardioembolic strokes (34%) and strokes of undetermined cause (33%) were the most common, with respective case-fatality rates of 16% and 18%. Large-vessel strokes (11%) and lacunar strokes (10%) were less common, with mortality rates of 3%. Conclusion - Stroke mortality is high and rapid following a hemorrhagic stroke and comparatively lower following an ischemic stroke, particularly for large-vessel or lacunar strokes.