Since the autumn of 2020, in the context of the pandemic, researchers, stakeholders and decision-makers have been sharing their knowledge and practices to help people experiencing homelessness better protect themselves from COVID-19. This knowledge mobilization in support of those living in precarious situations is called the MobCo approach. Led by Santé Publique France, the MobCo group provides a framework for knowledge exchange on strategies used to fight COVID-19 in France and abroad. By facilitating new partnerships and centralizing feedback from different regions, the MobCo approach has revealed promising avenues for action. In autumn 2020, MobCo brought together a group of 60 experts and field staff to discuss screening; in May 2021, a group of 120 participants convened to focus on vaccination. Here we provide an overview of MobCo's ongoing work.