Occupational diseases are reportable by law, but reports are rare. The French Institute for Public Health Surveillance (InVS) and the Occupational Health Inspectorate (IMT) have established an occupational disease surveillance program based on a network of volunteer occupational physicians. Each occupational physician reports all ODDs seen over a two-week period each semester. Sociodemographic data are collected to calculate ODD prevalence rates by sex, age, socioeconomic status, and industry sector. Participation by occupational physicians declined from 2008 to 2011 (from 33% to 19%). Reports of MCPs remained stable over this period among men (around 5%) but increased among women (6.2% to 6.9%). With the exception of hearing disorders, prevalence rates were higher among women. They increased with age up to the 45–54 age group. The prevalence rate of musculoskeletal disorders (MSDs) varied between 2006 and 2011 among men (2.6% to 3.1%) while remaining stable among women (around 3.5%). The prevalence of mental distress increased from 2006 to 2011 among men (0.9% to 1.3%) as well as among women (1.6% to 2.6%). A social gradient is observed for MSDs, whereas it is reversed for psychological distress. Industry and agriculture are the sectors most affected by MSDs. After adjustment, the sector of activity plays a lesser role in the occurrence of psychological distress than age and social class. Organizational and relational factors are risk factors for many MCPs. This program is part of the 2010–2014 occupational health plan. In 2012, 15 regions participated, and 13 in 2013. (R.A.)