Objectives: In France, data on the prevalence of Parkinson’s disease (PD) typically pertain only to specific geographic areas or populations. The objective of this report is to estimate the prevalence (incidence and prevalence) of PD in France for the general population. Methods: Using data on reimbursements for anti-Parkinson’s medications, we employed a validated approach to identify individuals treated for PD between 2010 and 2015. We also estimated the number of people newly treated each year. Frequencies were described by age, sex, region, and department. Results: At the end of 2015, 166,712 people were being treated for PD in France, representing 2.50 patients per 1,000 people. During the year, 25,842 people were newly treated, representing 0.39 patients per 1,000 person-years. The prevalence increases gradually with age up to age 80; more than half of patients are over 75 years old. Men are affected approximately 1.5 times more often than women. The geographic distribution of the disease is characterized by a certain degree of spatial heterogeneity. Conclusion: This is the first study on the prevalence of PD to cover the entire French territory and multiple health insurance schemes. These data contribute to a better understanding of the burden of PD at the national and subnational levels.