Introduction: Myocardial infarction (MI) is a major cause of morbidity and mortality in France. The objective of this study was to examine recent trends in the rates of hospitalizations for MI and MI-related mortality, with a specific analysis of women. Method: Myocardial infarction events were identified using the national hospitalization databases of the PMSI-MCO (2002–2013) and the medical causes of death from the CépiDc (2002–2012). Crude rates of hospitalizations and mortality by sex and age group were calculated and then age-standardized. Trends over the study period were analyzed using a Poisson model. Results: An increase in the rate of women under 65 hospitalized for MI was observed between 2008 and 2013, particularly among those aged 45–54 (+4.8% per year). This trend was less pronounced among men. Among those aged 65 and older, the decreases in rates for both sexes were small between 2008 and 2013 (-11.1% for women and -1.7% for men). Mortality from MI declined sharply among both men and women in all age groups between 2002 and 2012 (by more than 30%). Conclusion: Concerning trends in the annual incidence of MI in France are reported among women under 65 years of age. These trends may be linked to changes in certain risk factors, particularly smoking, for which additional preventive measures could be developed.