Introduction – Peripheral arterial diseases as a whole account for a significant proportion of morbidity and hospitalizations among patients with cardiovascular disease. Few epidemiological data are available in France on these conditions at the national and subnational levels. The objective was to describe the epidemiology of all aortic and peripheral arterial diseases (excluding intracranial arteries) in France in 2022, including the number and rates of hospitalized patients and their care, as well as the prevalence and mortality associated with these conditions. Methods – This study was conducted using the National Health Data System (SNDS). Adult patients hospitalized at least once for these arterial conditions in 2022 and those who died as a result of these conditions in 2021 were selected based on codes from the International Classification of Diseases, 10th Revision (ICD-10). The prevalence of peripheral arterial diseases among individuals alive as of January 1, 2023, was estimated by combining a history of hospitalizations with these diagnoses over the past 10 years with their eligibility for 100% coverage of the patient copayment under the Long-Term Illness (ALD) program. The corresponding prevalence and hospitalization rates were calculated by dividing the number of cases by the census data for the French adult population produced in the statistics of the National Institute of Statistics and Economic Studies (INSEE) for the same year. Results – In 2022, 68,702 adults were hospitalized in France for lower extremity arterial disease, 15,319 for aortic dissection or aneurysm, and 9,027 for dissection or aneurysm of a medium-sized artery, corresponding to rates per 100,000 inhabitants of 112.6, 28.7, and 16.9. The prevalence of these conditions in the adult population was 1.2% (n=760,047), 0.4% (n=200,000), and 0.2% (n=131,000), respectively. Significant regional disparities in age-standardized hospitalization rates were observed between mainland France and the overseas departments and regions (DROM), with higher rates in Réunion, as well as according to the social deprivation index of the municipality of residence. The one-year mortality rate ranged from 11% for patients hospitalized for a thoracic aortic aneurysm (TAA) or a dissection/aneurysm of a medium-sized artery, to 27% for those admitted to the hospital for an aortic dissection. The proportion of patients hospitalized for peripheral arterial disease (PAD) treated with antiplatelet agents or lipid-lowering drugs was 86% and 75%, respectively, one year after the index hospitalization, and was similar to those observed among patients hospitalized for an abdominal aortic aneurysm (AAA) (83% and 73%). Conclusion – The burden of aortic and peripheral arterial diseases is considerable in France, and mortality remains high for ruptured aortic aneurysms and aortic dissections.