Objective: The aim of this study was to assess regional variations in the hospital management of stroke patients during the acute and post-acute phases in France in 2015. Materials and methods: Hospitalized patients with stroke listed as their primary diagnosis—or, if admitted to multiple wards, with any primary ward diagnosis—were identified in the 2015 French national hospital discharge database for acute care. Hospitalization rates in stroke units (SUs) were assessed at the national level and in all metropolitan and overseas regions. All stroke survivors discharged at the end of the acute phase were subsequently identified in the national database for post-acute rehabilitation hospitalization (PARH) within 3 months. Results: During the acute phase, half of the stroke patients hospitalized for intracerebral hemorrhage, cerebral infarction, or unspecified stroke were admitted to SUs. However, there were variations across metropolitan regions (from 30% to 69%) and in overseas regions (from 1% to 59%); these rates correlated with regional ratios of SU beds per 100,000 inhabitants. There were also regional differences in PARH rates—among hemiplegic stroke patients, 62% were admitted for PARH (range: 58% to 67%) in metropolitan regions and, in overseas regions, from 8% to 67%—as well as geographical discrepancies in PARH rates to specialized rehabilitation units. Hospitalization rates for hemiplegic stroke patients in neurological rehabilitation centers were 30% for the entire country, but ranged from 23% to 36% in metropolitan regions and from 2% to 45% in overseas regions. Conclusion: This study focused on hospital-based management of stroke patients. Despite the creation of new specialized units (SUs) over the past decade in France, persistent regional differences remain in the number of SU beds per 100,000 inhabitants and, consequently, in the rate of stroke patients treated in SUs. However, rates continue to improve with the creation of new SUs and the expansion of existing ones. Regional variations were also observed in post-acute hospitalization rates and PARH beds/places.