The surveillance of healthcare-associated infections (HAIs) is a priority in intensive care, a high-risk setting due to patients’ critical condition and their exposure to invasive devices. Since 2004, the national REA-Raisin surveillance program, coordinated by the Network for Alert, Investigation, and Surveillance of HAI (Raisin), has focused in adult intensive care on infections associated with invasive devices for which a prevention strategy is essential: pneumonia (PNE), colonization, infection, or bacteremia (COL/ILC/BLC) associated with central venous catheters (CVC), and bacteremia (BAC). Each year, participating units collect data over a 6-month period on all patients hospitalized for more than 2 days (d). From January to June 2013, 213 departments included 34,278 patients (mean age: 63.9 years), hospitalized for an average of 11.7 days, of whom 69.0% were admitted to medical services, 18.3% to emergency surgery, and 12.6% to elective surgery; 7.7% of patients were trauma patients, 15.6% were immunocompromised, and 58.5% received antibiotic treatment upon admission. The mean IGS II score was 45.7, and the in-department mortality rate was 18.5%. Exposure to invasive devices was common: intubation (67.2%), CVC (61.2%), and urinary catheter (88.0%). Among the 34,278 patients, 10.5% developed at least one infection. The most frequently isolated microorganisms were P. aeruginosa (15.5%), S. aureus (12.2%), and E. coli (9.1%). Since 2004, antibiotic resistance has been decreasing for S. aureus strains (20.4% MRSA in 2013) while it has been increasing among Enterobacteriaceae strains (19.8% of strains producing ESBL and 1.6% resistant to imipenem). Incidence rates are 13.00 PNE per 1,000 intubation-days, 3.22 BAC per 1,000 hospital-days, 0.78 ILC, and 0.61 BLC per 1,000 CVC-days. These rates vary significantly from one department to another depending on patient characteristics. Over the past five years (2009 to 2013) across the entire network, certain risk factors have increased (age, IGS II, antibiotics on admission, immunosuppression, more patients in internal medicine and fewer in elective surgery), while exposure to invasive devices has decreased (exposure ratio for intubation, CVC, and urinary catheterization), and a significant decrease has been observed in all incidence rates per 1,000 days of exposure: PNE (-14.5%), BAC (-9.8%), BLC (-32.2%), and ILC (-29.7%). Multivariate analysis confirms the significant decrease in 2013 in PNE related to intubation (adjusted OR: 0.81; 95% CI: 0.76–0.87) and BLC (adjusted OR: 0.69; 95% CI: 0.54–0.86). With participation representing 47.2% of intensive care beds in France, the REA-Raisin data serve as a national benchmark for better understanding adverse events in intensive care and enable participating units to compare, evaluate, and guide their prevention efforts.