Hantavirus infections in humans have been monitored in France, particularly in mainland France, for about 30 years. During the 2012–2016 period, this surveillance involved a network of about 15 clinical laboratories, the National Reference Center (CNR) for Hantaviruses, and Santé publique France. Surveillance data were obtained by analyzing the information sheets accompanying samples from cases diagnosed by the network’s laboratories and confirmed by the NRC. The observed situation was similar to that reported for previous periods: an average of about 100 cases per year, most of whom were hospitalized (incidence of 0.15 cases per 100,000 inhabitants), with significant annual variations. The working-age population was consistently the most affected (median age of 40 years) and men were the most affected (75% of cases). Cases were detected year-round, with detection peaks in late spring or fall. The majority of cases were caused by the Puumala virus, but the key finding during this period was the detection of infections caused by the Seoul and Tula viruses and the nature of exposure to these viruses. The geographic distribution of cases, concentrated in the northeastern quarter of France, showed very limited expansion into surrounding areas. However, this incidence and geographic distribution may be underestimated due to the use of overly specific serological diagnostic tests and low demand for diagnosis among non-hospitalized patients or those outside the known endemic area.