Reducing the incidence of surgical site infections (SSIs) is one of the objectives of the national program to combat nosocomial infections (NI). Since 1999, interregional surveillance of SSIs has been coordinated by the Network for Alert, Investigation, and Surveillance of Nosocomial Infections (Raisin). Each year, participating surgical departments collect data from a list of "priority" specialties regarding the patient and the procedure, including components of the NNIS risk index. All included patients must be followed up through the 30th postoperative day (90 days for orthopedic surgery). SSI cases are defined according to standard criteria. In 2014, the number of departments participating in the surveillance of priority procedures decreased slightly compared to 2013: 915 surgical departments. However, the number of procedures monitored remained the same (107,656 procedures). The breakdown of specialties and their respective ISO rates were: 287 (29.6%) gastrointestinal surgery departments (ISO rate = 1.72%), 278 (24.5%) orthopedic departments (0.97%), 287 (24.0%) obstetrics and gynecology departments (1.68%), 118 (7.1%) lower limb venous excision surgery departments (0.43%), 107 (6.1%) trauma departments (0.62%), 108 (5.1%) urology departments (2.90%), 47 (2.4%) neurosurgery departments (0.69%), and 10 (1.1%) coronary surgery departments (2.76%). As noted in previous years, not only has the slowing of the decline in incidence been confirmed, but in 2014, there was also an increase in ISO rates for breast surgery, abdominal wall hernias, and transurethral resections of the prostate. The influence of tobacco on the incidence rate of SIS was demonstrated in digestive surgery, and that of diabetes and hypertension in gynecology and obstetrics. A prescription for antibiotic prophylaxis (AP) recommended by the SFAR and administered was a protective factor against the incidence of SIS in gynecology-obstetrics and neurology (compared to recommended prescriptions that were not administered). Finally, in urological surgery, a recommended, administered, and compliant AP prescription was also a protective factor against the incidence of SIs (compared to a recommended prescription that was administered but did not comply with the SFAR guidelines).