Under the auspices of the Network for the Alert, Investigation, and Surveillance of Nosocomial Infections (Raisin) and in collaboration with the Study Group on Healthcare Workers’ Risk of Exposure to Infectious Agents (Geres), methods for monitoring blood-exposure incidents (BEIs) have been the subject of a consensus and a national network since 2002. Each facility voluntarily, anonymously, and in a standardized manner documented all BSE incidents involving a staff member (including students and interns) reported to the occupational physician from January 1 to December 31, 2007. Data were collected on a form adapted from Geres documenting the circumstances of the BSE (nature, mechanism, equipment involved), its follow-up (immediate care, follow-up, and any prophylaxis), and the infectious status of the source patient. The incidence of blood-borne exposure incidents was reported relative to the number of hospital beds, the number of full-time equivalent (FTE) staff, and the consumption of certain medical devices. In 2007, 15,605 blood exposure incidents were recorded in 626 facilities. The network’s national coverage can be estimated at 22% of healthcare facilities and 46% of beds, representing an expansion compared to 2006 (18% and 42%, respectively). The HCV and HIV status of the source patient, which determines the subsequent management of the healthcare worker, remains unknown in more than 20% of cases. The rate of prescribing antiretroviral chemoprophylaxis continues to decline, as it was prescribed in 4% of blood exposure incidents in 2007 versus 6.3% in 2002. Treatment was discontinued in 41% of cases, most often due to the retrospective determination that the source patient was HIV-negative. The median time to care for a healthcare worker following a NAI was one hour, demonstrating the highly operational nature of this system in France. Since 2004, suture needles have ranked first among needle-related NPA incidents, ahead of subcutaneous needles. These NPA incidents account for 10% of all accidents occurring in the fields of surgery, obstetrics, as well as intensive care and emergency medicine. It therefore remains necessary to prioritize the safety of this procedure and promote the use of blunt-tip needles. Compliance with glove use among healthcare workers involved in accidents and the proximity of a sharps container increased from 58% to 67% and from 66% to 72%, respectively, between 2002 and 2007, which still represents a high number of high-risk situations. Although it is improving, the rate of safety equipment use remains low in documented healthcare-associated infections (HAIs), at 31% for short catheters and 32% for implantable port needles, compared to 26% and 24%, respectively, in 2005. The incidence of HAIs per 100 hospital beds is 7.5. Based on the 448,505 hospital beds recorded in France (2006 SAE data), this allows us to estimate the number of AES reported in 2007 to occupational physicians in French healthcare facilities at 33,638 (95% CI: 33,293–33,983). If we put this figure into perspective with the 2004 data from the same network—namely, an incidence of 8.9% and an estimated number of AES of 41,429—this represents a decrease of nearly 8,000 AES. Although this is only a fairly empirical estimate, it suggests that significant progress in terms of patient safety has been made in France during this period. Continuing and strengthening this momentum will be the objective of the 2009–2012 national program for the prevention of nosocomial infections. The stated goal of this program is to further reduce the incidence of healthcare-associated events by 25%. (R.A.)