Background: Accidental exposure to blood and other body fluids is a major occupational hazard for healthcare professionals. Reducing the incidence of such exposures is one of the priorities of the national strategic plan for the prevention of healthcare-associated infections and the national program for the prevention of healthcare-associated infections. Surveillance of BSE in France has been standardized since 2002 and is led by the national "Raisin" network (Network for Alert, Investigation, and Surveillance of Nosocomial and Healthcare-Associated Infections), in collaboration with Geres (Study Group on Healthcare Workers’ Exposure Risk). Objective: To monitor healthcare-associated infections (HAIs) in French healthcare facilities (HCFs). Methods: Participation by HCFs in this surveillance network (AES-Raisin) is voluntary and anonymous. HAIs were documented using a standardized questionnaire adapted by GERES. The questionnaire documents the nature, circumstances (mechanism, type of device, infectious status of the source), and follow-up of each AES. The occurrence of AES was reported in relation to the number of hospital beds, the number of healthcare professionals (in full-time equivalents), and the use of certain medical devices. Results: 17,148 AEs in 2011 and 18,829 AEs in 2012 were documented in the 849 healthcare facilities participating in 2011 and in the 1,019 healthcare facilities participating in the surveillance network in 2012, respectively, representing 39.3% of healthcare facilities and 72.3% of hospital beds for the latter year. The participation rate in the AES-Raisin surveillance system has been steadily increasing since 2003. The overall incidence of AES was 6.6 with a 95% CI [6.5–6.7] in 2011 and 6.3 with a 95% CI [6.2–6.3] in 2012, ranging from 1.0 (95% CI [0.9–1.1]) to 16.0 (95% CI [14.9 to 17.1] depending on occupational categories. For all participating healthcare facilities and in the stable cohort of 342 hospitals that participated every year from 2008 to 2012, the incidence rates of AES per 100 beds decreased by 14.9% and 13.9%, respectively. Percutaneous injury was the most common cause of reported AES, accounting for 14,885 AES in 2012, or 79% of the total, primarily involving puncture wounds (n=12,842), half of which were related to needle handling (48.8%), which remains the main type of reported exposure. The increasing use of safety devices was observed over the study period. Within the stable cohort, compliance with glove use in healthcare facilities reporting AEs rose from 67.7% in 2008 to 72.5% in 2012, and the availability of sharps containers increased from 69.9% in 2008 to 73.7%. In 2012, however, NSI remained a preventable event through adherence to standard precautions in 30.9% of cases (4,602 out of 14,885). Within the stable cohort between 2008 and 2012, a statistically significant decrease in the proportion of preventable NSI (-18.8%) and, among these, NSI due to recapping errors (-11.4%) was observed. Conclusions: Our results suggest that the safety of healthcare professionals’ practice has greatly improved over the past ten years in France. In conclusion, by participating in this surveillance, healthcare professionals have a better understanding of adverse events, which allows for the optimization of their prevention. However, these efforts should be continued to maintain and further optimize the safety of practice. (R.A.)