The ATB-Raisin antibiotic consumption monitoring system contributes to the appropriate use of antibiotics. Its objectives are to enable each healthcare facility (HCF) to describe and analyze its antibiotic consumption and to compare these figures with bacterial resistance data by benchmarking against a comparable group of HCFs. Systemic ATBs in class J01 of the Anatomical Therapeutic Chemical (ATC) classification, rifampicin, oral imidazoles, and fidaxomicin, as well as systemic antifungals in class J02 (optional component), dispensed during inpatient stays, were expressed in defined daily doses (DDD) and reported according to national and World Health Organization recommendations (ATC-DDD system, 2016). Resistance data were collected for seven bacteria/antibiotic pairs to enable each healthcare facility to assess its situation regarding selection pressure, on the one hand, and the clinical context contributing to the use of certain antibiotics, on the other. The 1,470 participating healthcare facilities accounted for 69% of hospital days in France in 2016 and had consumed 371 DDDs per 1,000 hospital days (HD). The most commonly used antibiotics were the amoxicillin-clavulanic acid combination (31%), amoxicillin (19%), and ceftriaxone (6%). Antibiotic consumption ranged from 56 DDD/1,000 HD in psychiatric hospitals to 629 in military teaching hospitals. Variations were observed across different specialties, ranging from 60 DDD/1,000 patient-days in psychiatry to 1,468 in intensive care. Among the 490 healthcare facilities that have participated every year since 2009, consumption increased most significantly between 2009 and 2013 (+4.1%). Since 2013, the trend has been downward, despite a slight increase of +0.7% between 2014 and 2015 (-7% between 2013 and 2016), and total consumption in 2016 was comparable to that of 2009. Consumption of carbapenems, third-generation cephalosporins, the piperacillin-tazobactam combination, and imidazoles had increased, while that of fluoroquinolones and glycopeptides had decreased. Resistance data were consistent with those from specific networks. Antifungal consumption was higher in hematology (188 DDJ/1,000 patient-days) than in intensive care (143 DDJ/1,000 patient-days). Network-based surveillance allows each healthcare facility to analyze its situation, exchange information on practices and organizational structures, and track evolving trends. The analysis of antibiotic consumption should be supplemented by an evaluation of practices and the monitoring of indicators reflecting the quality of prescribing.