In an initial report published in 2020, Santé publique France confirmed the importance of implementing epidemiological surveillance around industrial clusters, which are areas of cumulative exposure and raise concerns among nearby residents regarding their potential impact on health. This second report aims to consolidate the list of industrial basins identified in France and to describe them—in terms of activities and discharged substances—using existing databases (specifically the ICPE database, the nomenclature database, and the IREP database). The creation of a flowchart defining a major industrial cluster based on specific criteria enabled the compilation of a final list of French industrial clusters. It thus consists of 42 clusters identified by zones of concentration of IED and/or Seveso industries, 7 clusters that were the subject of a zone study, and 3 derived from national gray literature. The clusters are present throughout mainland France and the overseas territories. They account for 8% of ICPEs, 17% of IEDs, and 31% of Seveso facilities in France. Industrial clusters exhibit great diversity in terms of number, status, and type of industries. Similarly, the industrial activities present in each cluster are highly varied; only certain basins, such as Grasse or Cognac, stand out with specific activities (perfume manufacturing and alcoholic beverage production, respectively). Activities related to the ICPE classification (family 2), and more specifically those involving waste, materials, ores, and metals, as well as chemicals, are the most commonly reported within industrial basins. In 2016, 13% of the ICPEs in the basins reported at least one discharge exceeding the regulatory threshold in IREP, notably for CO2, NMVOCs, NOx, or SOx. The basins of Dunkirk, Fos-sur-Mer, and Le Havre-Gonfreville reported the highest number of discharges. The databases used have numerous limitations, such as a lack of historical depth in the data, inaccuracies in geolocation, and missing data, which made it difficult to analyze the data and describe certain basins. This report serves as a progress report in anticipation of the multicenter epidemiological study that will be conducted around the industrial basins.