Objective: The Asian hornet (Vespa velutina) (Vv) is an Asian hymenopteran first reported in France in Lot-et-Garonne in 2004 [1]. Since then, Vv has been spreading northward and westward at a rate of approximately 100 km per year. By 2013, the species had colonized 62 departments, representing more than 50% of French territory. An initial toxicovigilance report on Vv was published in 2009 [2]. The present study provides an update on the situation in mainland France between 2009 and 2013. Methods: Two data sources were analyzed to assess the health impact of hymenoptera stings across France from 2009 to 2013 (surveillance period: April to October): the health surveillance system for emergency cases and deaths (SurSaUD®/Oscour®) and the joint information system of poison control centers (Sicap). Results: In the SurSaUD®/Oscour® data, summer peaks between 2009 and 2013 ranged from 308 to 889 cases per week, corresponding to 2.8 to 3.5 cases per 1,000 emergency department visits for all causes combined. In Sicap over the same period, 2,816 hymenoptera stings were reported to the CAPTVs, with weekly summer peaks of 37 to 56 cases of envenomation, or 24.5 to 33.8 stings per 1,000 cases of exposure from all agents combined. There is a very close correlation between SurSaUD®/Oscour® data and Sicap data, with a ratio of approximately 10 between the two data sources. Nationally in Sicap, 202 severe cases of hymenoptera stings were recorded from 2009 to 2013, representing 7.2% of the total number of cases. The clinical manifestations reported for these severe cases were: facial edema/angioedema (37.6%), hives (36.6%), and anaphylactic shock (23.8%). Among the 2,816 cases of hymenoptera stings, 540 cases (19%) mentioned a hornet sting without specifying the species, and 135 cases (5%) mentioned an Asian hornet sting. An increase in cases associated with Asian hornet stings is evident (n < 10 cases in 2009 vs. n > 30 since 2011), but caution is warranted regarding reporting bias. From 2009 to 2013, 71 severe cases of hornet stings out of a total of 202 severe cases (35%), including 17 linked to Asian hornets, have been recorded in Sicap since 2009, amounting to fewer than 25 cases per year. Over these 5 years, 4 deaths attributed to "Asian hornets" were recorded in SICAP, with the species having been formally identified in only one of these cases. Two deaths occurred in 2011 (a 59-year-old woman and a 65-year-old man in Aquitaine) and the other two in 2012 (a 68-year-old woman in PACA and a 54-year-old man in Pays-de-Loire). All four deaths were linked to anaphylactic shock. Three of the patients had a known history of allergy to hymenoptera venom: they could therefore have developed complications following a sting by a hymenoptera other than an Asian hornet. Conclusion: Between 2009 and 2013, a stable number of hymenoptera stings was recorded in the SICAP database and by the Oscour® network. The annual incidence of venom-related cases remained constant, despite the nationwide spread of Vv. During the 5-year study period, severe cases related to hornets (including Vv) remained infrequent (fewer than 25 cases per year), and deaths recorded by CAPTVs were rare. Stings by Asian hornets do not appear to pose a higher risk of severity compared to stings by other species of hymenoptera.