Background: Among the biomechanical stressors associated with musculoskeletal disorders (MSDs), postural stressors (PS) are among the most commonly observed in workers. The objective of this study was to assess the associations between exposure to organizational and psychosocial factors and exposure to at least one PS for 10 hours per week in the French working population. Methods: This study is based on data from the 2010 Sumer survey. Socio-professional and organizational characteristics were reported by the occupational physician, and psychosocial factors were reported by the employees themselves using a self-administered questionnaire. Associations between organizational and psychosocial factors and exposure to a PC were explored using logistic regressions. Results: Exposure to at least one CP for 10 hours per week was observed in 14% of men and 12% of women. Industrial constraints, production standards, lack of flexibility, hierarchical supervision, and job versatility were positively associated with exposure to a CP, regardless of gender. Similarly, a harmful psychosocial environment (low social support, limited use and development of skills, and high psychological demands) was associated with an increased risk of exposure to a CP. Conclusion: These results suggest the need to consider organizational and psychosocial dimensions, beyond biomechanical and socioprofessional factors, in the prevention of MSDs in the workplace.