The observed prevalence of rotator cuff syndrome (RCS) in a sample of 3,710 randomly selected employees in the Pays de la Loire region between 2002 and 2004 was 7%. The objective of this article is to describe the progression in 2007 of 207 employees who had been diagnosed with RCS by their occupational physician. Shoulder symptoms remained the same or worsened for two-thirds of them. Occupational exposure to biomechanical stressors remained significant among those still working, and adjustments to working conditions were made for only a minority. Quality of life and shoulder function were lower among those who were no longer working. This study shows that for aging employees, particularly those with RSI, reducing exposure and maintaining or returning to work remain priority areas for action. (R.A.)