Introduction – Foot ulcers in people with diabetes are serious complications resulting from neuropathy and/or peripheral artery disease. They do not develop suddenly, but rather after years of disease progression and structural changes in the foot. They represent a major cause of morbidity, profoundly impair quality of life, and are the leading cause of non-traumatic amputation in developed countries. Objective – This literature review aims to explore the link between socioeconomic vulnerability—both individual and regional—and the incidence, management, and prognosis of diabetic foot ulcers.Results – Numerous studies show a consistent association between socioeconomic vulnerability and an increased risk of foot ulcers and amputations. People with low incomes, low levels of education, or without adequate health coverage have limited access to preventive care, particularly podiatric care, leading to later diagnosis and a poorer prognosis. The most disadvantaged regions also have a higher incidence of wounds, amputations, and mortality. However, structured, multidisciplinary care pathways, along with an efficient regional primary care network, can mitigate these inequalities.Conclusion – Socioeconomic disadvantage has a major negative impact on the development and progression of diabetic foot ulcers. Effective regional organization, improved access to specialized care, and a comprehensive approach that integrates social determinants are essential for preventing complications and reducing the number of amputations.