Pertussis is a highly contagious respiratory disease. Its severity stems from its bronchopulmonary complications and high mortality rate among infants. The introduction of the whole-cell vaccine in 1959, and especially its widespread use beginning in 1966, led to a dramatic decline in the number of cases in France. However, eliminating the disease is not feasible today because the protection provided by the vaccine wanes after a few years. The results of epidemiological surveillance from 1996 to 1999, which has been conducted since April 1996 through the RENACOQ pediatric hospital network, are presented in this article. The network’s data for 1999 are fairly comparable to those of previous years. Key points include an increase in biologically confirmed cases, greater use of PCR, and an increase in vaccinated cases. The upcoming analysis of the 2000 data will help determine whether these trends are confirmed.