Key Points

• In 2025, 21 cases of leptospirosis were reported among residents of Normandy, including 13 confirmed cases and 8 probable cases.
• The cases primarily involved men, with a median age of 39 years.
• The Calvados department was the most affected in Normandy, with 9 reported cases, corresponding to an incidence rate of 1.27 per 100,000 inhabitants.
• The most frequently reported risk exposures were contact with animals (n = 11), primarily rodents (n = 6), as well as freshwater activities (swimming, canyoning, etc.) (n = 10). However, half of the exposure sites were located outside Normandy.
• Nearly all cases were hospitalized, with a significant proportion admitted to intensive care, underscoring the potential severity of this zoonosis. No deaths related to this disease were reported in Normandy in 2025.
• Mandatory reports (MRs) were submitted to the ARS within a median of 9 days. These results underscore the importance of early diagnosis and rapid reporting to enable the implementation of targeted prevention measures focused on high-risk exposures.