Under the auspices of the Network for the Reporting, Investigation, and Surveillance of Nosocomial Infections, and in collaboration with the Study Group on Healthcare Workers’ Risk of Exposure to Infectious Agents, methods for monitoring blood-exposure incidents (BEIs) have been the subject of a consensus and a national network since 2002. All BSE incidents reported to the occupational physician from January 1, 2008, to December 31, 2008, were documented on a voluntary, anonymous, and standardized basis. In 2008, 16,282 BSE incidents were recorded, 65% of which were reported by paramedical staff, and 80.6% were percutaneous injuries, primarily caused by needle sticks. Compliance with glove use (67.8%) and proximity to the specimen container (70.9%) has improved. However, standard precautions were not followed in 45.8% of percutaneous AES, resulting in a still high number of preventable accidents. The source patient’s status remains unknown in 20% of cases. The prescription of antiretroviral chemoprophylaxis is decreasing (3.4% in 2008 versus 6.3% in 2002). National network coverage in 2008 (25.6% of healthcare facilities and 50.7% of beds) is increasing. The incidence is 7.4 AES per 100 hospital beds. Based on the 434,809 hospital beds recorded in France, 32,176 AES were reportedly reported in 2008 to occupational physicians at French healthcare facilities. When comparing these results with those from 2004 (an incidence of 8.9 and an estimated 41,429 AES), this represents a decrease of approximately 9,250 AES. Although the estimate is empirical, this suggests that significant progress has been made in terms of patient safety. Continuing and strengthening this momentum is the objective of the 2009–2013 National Program for the Prevention of Nosocomial Infections. (R.A.)