In 2025, 6,529 emergency department visits within the OSCOUR® network related to cocaine use and 2,096 hospitalizations following those visits were recorded. This represents an average of 125 emergency department visits related to cocaine use per week in France in 2025. After a stabilization in the number of emergency department visits related to cocaine use in 2024, a marked resumption of the upward trend was observed, returning to the pattern that had been in place since at least 2012. Significant regional disparities are observed, with very high rates of visits in Brittany, French Guiana, and Provence-Alpes-Côte d’Azur. The majority of visits still involve men (71%), and the median age is 33, which corresponds to the profiles typically observed among the heaviest cocaine users in the general population. Visits related to cocaine use are frequently associated with the use of other substances. Observations based on emergency department visit data and inquiries received by the Drogues Info Service follow the same trends.