Human reproduction is a particularly sensitive biological function. For several decades, changes in reproductive functions have been reported in humans, contributing to the interest that public authorities have in reprotoxic chemicals. In 2004, the French Agency for Environmental and Occupational Health Safety (Afsset) proposed developing French expertise on toxicological reference values (TRVs) based on reprotoxic effects. One of the objectives was to identify chemicals with reprotoxic potential in order to prioritize them and better focus the work on developing TRVs. A list of potentially reprotoxic substances was compiled based on regulatory classifications and informational lists of reprotoxic substances in Europe and the United States. A total of 445 potentially reprotoxic substances were identified. These substances were prioritized based on the relevance of the data sources used and the occurrence of the substances in the selected priority lists. A total score, calculated as the product of indirect hazard and exposure scores scaled to a common value scale, was assigned to each substance. The substances identified as being of greatest concern are certain phthalates, metals, glycol ethers, and alkylphenols. The score-based approach is widely used in priority setting at both the European and international levels. Although a number of limitations have been identified in the proposed method, it appears useful as a preliminary step toward a thorough study of the feasibility and relevance of developing a VTR based on reproductive toxicity effects for substances deemed to be priorities. (R.A.)