Between May and November 2020, the prevalence of depressive disorders among people aged 15 and older fell from 13.5% to 11.0%, returning to a level equivalent to that recorded in 2019, according to the EpiCov and EHIS surveys. This overall decrease is driven by a two-point drop in minor depressive symptoms, affecting 6.1% of the population; however, major depressive symptoms (4.9%) did not decline over the period and remained at levels higher than those of 2019, particularly among young people. During 2020, one in five people experienced a depressive syndrome in May or November, and nearly one in twenty had a persistent depressive syndrome during both periods. Young people, women, people with disabilities, those facing difficult economic circumstances and/or those whose situation has worsened due to the health crisis, and those who have experienced symptoms suggestive of COVID-19 are the most affected. In November 2020, 2.8% of the population reported having thought about suicide in the past twelve months; this figure rises to 5.0% among 15- to 24-year-olds, and the proportion of people affected decreases with age. 4.0% reported having attempted suicide at some point in their lives, and for 0.2%, this attempt occurred within the past twelve months. Finally, EpiCov data show a decline in the rates of regular alcohol and cannabis use compared to previous data, but they indicate an increase of more than 20% in the number of psychotropic drug users during 2020.