One of the objectives of the national biomonitoring program led by Santé publique France is to develop exposure reference values (ERVs) for the French population. These ERVs indicate, in the form of a summary value, the background level of exposure of the population—or specific population subgroups—to a given substance at a given time. Their use allows for the comparison of exposure levels at the local or international level. They serve as a decision-making tool in the implementation of health management measures at the local level and, at the national level, enable the evaluation of the effectiveness of public policies implemented to limit exposure to chemicals of concern. However, these VREs do not allow for the direct characterization of the health risk associated with a given exposure level. In order to establish a standardized framework for developing French VREs and to ensure good comparability with international values, it was necessary to define a strategy for developing VREs based on French biomonitoring data. The strategy for developing VREs presented in this report aims to harmonize the process of producing VREs based on French biomonitoring data. This strategy is based on an analysis of options used internationally and draws inspiration from the choices adopted by the majority of scientific experts in human biomonitoring worldwide (Germany, Canada, the Czech Republic, Brazil, etc.), namely the use of the 95th percentile of the distribution of body burden levels as the basis for deriving VREs. The successive application of exclusion, authorization, and partitioning criteria to biomonitoring data ensures the production of standardized French VREs that are internationally comparable. The efforts undertaken as part of this work will contribute to the definition of a European strategy for developing VREs within the framework of the HBM4EU project.