Key Findings: Changes in Smokers’ Desire to Quit and Smoking Behaviors During the Health Crisis The proportion of daily smokers wishing to quit was estimated at nearly 60% in the first half of 2020, during which the first COVID-19-related lockdown was implemented. This proportion was similar to those of previous years. The majority of smokers residing in mainland France (between half and two-thirds, depending on the surveys included in this study) reported that the health crisis had not influenced their consumption or their motivation to quit smoking. Among the remaining minority, changes in tobacco consumption during the pandemic were highly dependent on employment status (teleworking, job loss) and the level of stress experienced during the health crisis. While people accustomed to smoking during social gatherings reduced their consumption due to the decline in social occasions, smokers who viewed cigarettes as a means of relieving stress tended to smoke more during the crisis. Motivations and Barriers During the Pandemic The three main motivations for quitting smoking reported in 2020 and 2021 were health, the cost of smoking—which was more pronounced among some smokers due to the economic hardships caused by the pandemic—and weariness with addiction. Smokers wishing to quit were primarily concerned about withdrawal symptoms (weight gain, irritability, etc.), a reduction in social connections, and the loss of the support provided by smoking. Despite a very solitary and fatalistic perception of quitting—relying solely on willpower—they were highly receptive to support from those around them and to the availability of support tools. Opportunity for an anti-smoking campaign during the COVID-19 crisis While the smokers surveyed stated they were aware of the risk tobacco poses to the development of severe forms of COVID-19, most were nevertheless opposed to using this as a lever in prevention campaigns. The smokers surveyed struggled to view the health crisis as a good opportunity to quit. They almost unanimously believed that it was useful and legitimate to continue anti-smoking campaigns during this crisis.