Objective: This study updates the estimates and trends in smoking-attributable mortality in metropolitan France between 2000 and 2015, the last year for which mortality data are currently available. Method: The estimates were calculated using the same approach as that implemented by Bonaldi et al. in 2016 to estimate smoking-attributable mortality in France between 2000 and 2013. The method is based on the estimation of attributable fractions calculated by combining mortality data, lung cancer death rates, and adjusted relative risks of death for all smoking-related diseases. Results: In 2015, it was estimated that more than 75,000 deaths were attributable to smoking, corresponding to approximately 13% of deaths occurring in metropolitan France. Between 2000 and 2015, the proportion of attributable deaths appears to have declined over time for men, whereas this same proportion among women has increased continuously by more than 5% per year on average. Conclusion: This estimate of mortality attributable to smoking in France once again highlights the considerable health impact of tobacco on the French population. It is essential that the efforts driven by the National Tobacco Control Program continue in order to reduce the health burden of smoking in France.