Salmonella transmission via reptiles has been reported in many countries, most commonly among children. To describe cases of reptile-transmitted Salmonella infections in young children in France, an investigation was conducted in 2012 among children under 5 years of age with salmonellosis caused by a serotype confirmed by the National Reference Center for Salmonella and previously described as being carried by reptiles in the literature. The children’s parents were interviewed by telephone using a questionnaire regarding clinical presentation, the occurrence of symptoms among household contacts, recent travel, and contact with animals. Thirteen of the 41 children included (32%) had been exposed to reptiles, including one through direct contact. The isolated strains belonged to 9 different serotypes. The main animals involved were turtles (6 cases). Two children developed meningitis. In one of these two cases, the same Salmonella strain was identified in both the patient and his pet lizard. Twelve of the 13 families investigated were unaware of the risk of Salmonella transmission by reptiles prior to their child’s illness. This investigation confirms that in France, pet reptiles can cause salmonellosis—sometimes severe—in young children, even in the absence of direct contact, and underscores the importance of providing information about this risk. (R.A.)