Salmonella infections are one of the leading causes of foodborne bacterial infections. This article describes recent trends and changes in Salmonella serotypes studied at the National Reference Center for Salmonella (CNR-Salm) from 2002 to 2010, as well as the characteristics of the major salmonellosis outbreaks detected during this period in France. Between 2002 and 2010, an overall 20% decrease in the number of Salmonella reports at the CNR was observed, linked to a significant decline in the number of Enteritidis serotype strains as well as Typhimurium serotype strains, along with the emergence of monophasic variants of Typhimurium detected by the surveillance system. During the same period, 26 major salmonellosis outbreaks were the subject of in-depth investigations. Despite a notable decrease in the number of Salmonella infections, the emergence of new serotypes, the multiplicity of Salmonella reservoirs, and the development of antibiotic resistance in strains call for continued vigilance in order to adapt recommendations and control measures. (R.A.)