Introduction: The Primo initiative focuses on the surveillance and prevention of antibiotic resistance and healthcare-associated infections in community-based care and the medical-social sector. The 2019 national data on antibiotic resistance in community settings and nursing homes are presented for three bacterial species of interest (Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus). Method - From January 1 to December 31, 2019, susceptibility test results for E. coli, K. pneumoniae, and S. aureus isolated from diagnostic specimens were collected from a network of 1,016 clinical laboratories (LBM) spread across the 13 regions of metropolitan France. Administrative and microbiological data were uploaded by the CLS to a dedicated electronic surveillance platform. Antibiogram data for strains isolated from patients living at home or residing in long-term care facilities were included in the analysis. Data from hospitalized patients and screening samples were excluded. After deduplication, resistance rates were calculated as the number of antibiotic-resistant strains divided by the total number of strains tested for that antibiotic. Statistical analyses were performed using Student’s t-test or analysis of variance (ANOVA). 95% confidence intervals and laboratory-weighted percentages were determined. Results - In 2019, 558,819 antibiotic susceptibility tests performed on Enterobacterales strains isolated from urine specimens (of which 87.3% were Escherichia coli and 8.4% were Klebsiella pneumoniae) were collected by the Primo and Spares surveillance programs. Among patients living at home, 3.4% of isolated E. coli strains were resistant to third-generation cephalosporins (C3G) and 3.0% produced extended-spectrum beta-lactamases (ESBLs). Among nursing home residents, resistance to 3GCs was observed in 9.9% of E. coli strains, and 8.7% were ESBL-producing. Fluoroquinolone resistance in E. coli was 11.4% for strains isolated from home-dwelling patients and 19.1% for those isolated from nursing home residents. The annual proportions of ESBL-producing and fluoroquinolone-resistant E. coli were slightly higher in 2019. Among K. pneumoniae, ESBL production was observed in 7.7% of strains isolated from outpatients and 15.7% of those isolated from nursing home residents. The proportion of fluoroquinolone-resistant strains was 11.0% among patients living at home and 20.2% among nursing home residents. Among the 30,675 S. aureus susceptibility test results collected, 76.7% were from superficial swabs. Among patients living at home, 9.3% of S. aureus were methicillin-resistant, and 36.4% in nursing homes. Conclusion - The Primo surveillance program provides insights into the bacterial ecology in community and long-term care settings, where 93% of antibiotics are consumed. The slight increases in rates of ESBL and fluoroquinolone resistance encourage us to continue efforts to control antibiotic resistance in these sectors.