Introduction - In France, surveillance of human Campylobacter infections is based on a network of volunteer laboratories. This surveillance enables the epidemiological characteristics of the disease to be described, clusters of cases to be detected, and antibiotic resistance to be monitored. Materials and Methods - A case is defined as the isolation of a Campylobacter strain from a biological specimen. Participating volunteer laboratories send each isolated strain to the National Reference Center (NRC) for Campylobacter and Helicobacter for species identification and antibiotic susceptibility testing. Results - The annual number of strains received by the NRC increased by 97% between 2003 and 2010. The median age of infected individuals was 24 years (range: 0 months–100 years). On average, 25% of the strains isolated annually were from children under 6 years of age, and 45% of the strains were isolated each year between June and September. Resistance to quinolones reached 49% for C. jejuni and 79% for C. coli in 2010. Conclusion - Surveillance data from 2003 to 2010 show an increase in the number of Campylobacter infection cases since 2003, a marked summer peak, and high and rising resistance to quinolones. (R.A.)