Objectives - To assess the prevalence of persistent joint symptoms following infection with the chikungunya virus (CHIKV) and to investigate the factors associated with the persistence of joint symptoms. Methods - Between June and September 2006, we conducted telephone interviews with a cohort of patients aged 16 years and older who had had a confirmed CHIKV infection 12 to 18 months prior. Results - Of the 147 individuals included in the study, 69% were women. The median age was 52 years (25th–75th percentile: 43–63). This study revealed a high prevalence of joint symptoms within this cohort, as 84 participants (57%) reported joint symptoms 12 to 18 months after infection. Among these 84 patients, 53 (63%) reported persistent symptoms and 31 (37%) reported occasional symptoms. After adjusting for sex, age > 45 years (OR 3.9; 95% CI 1.7–9.7), the severity of initial joint pain (OR 4.8; 95% CI 1.9–12.1), and a history of osteoarthritis (OR 2.9; 95% CI 1.1–7.4) were found to be significantly associated with the persistence of symptoms. Conclusion—These results should enable better identification in the future of individuals at risk of progression to chronicity. (R.A.)