Key Points

• In the Grand Est region, while vaccination coverage among infants subject to the mandatory vaccination requirements in effect since 2018 is high for vaccinations against diphtheria, tetanus, polio, pertussis, Haemophilus influenzae type b, and hepatitis B, as well as pneumococcal and meningococcal C; it remains insufficient for vaccination against measles, mumps, and rubella, with coverage of 86.8% for the second dose of this vaccine. Given the current circulation of the measles virus, only two-dose vaccination coverage of at least 95% is likely to interrupt transmission of the virus.

• 72.6% of infants born in 2023 received at least one dose of the meningococcal B vaccine, representing a 26-point increase compared to the previous year.

• 34.5% of infants born in 2023 received at least one dose of the rotavirus vaccine in the region. Significant disparities among departments are observed for this vaccination, which has been recommended since 2023.

• Although meningococcal C vaccination coverage has increased by 4 percentage points among adolescents in the Grand Est region, catch-up vaccination remains very insufficient among young people aged 15 to 19, with a vaccination coverage rate of 47.3%.

• 58.5% of 15-year-old girls and 28.4% of 15-year-old boys have started their HPV vaccination series. HPV vaccination coverage increased in 2023, with a 6-point gain among girls and coverage that doubled among boys compared to 2022. Despite this progress, HPV vaccination coverage remains far from the 80% target set in the 10-year cancer control strategy for 2030.

• At the end of the first phase of the human papillomavirus (HPV) vaccination campaign in middle school, as of December 31, 2023, it is estimated that approximately 58% of girls and 47% of boys aged 12 (born in 2011, mostly enrolled in 7th grade) had received at least one dose of the HPV vaccine. An increase of 17 percentage points among girls and 18 percentage points among boys in vaccination coverage was observed between the start and end of the first phase of the campaign, although it is not yet possible to specify the gain directly attributable to the campaign. These estimates take into account vaccinations administered in middle schools and in the community.

• Vaccination coverage against influenza, COVID-19, and shingles remains insufficient among at-risk individuals. Influenza vaccination coverage is declining among people with risk factors, with low coverage among those aged 65–74 (46.7% vs. 51.0% in 2022–23). COVID-19 vaccination coverage is 28.6% among those aged 65 and older. Less than 3% of people aged 65–74 are vaccinated against shingles.