Introduction - The objective of this study is to compare two InVS surveillance programs, MCP (Occupational Diseases) and Samotrace, in the field of occupational mental health. Methods - Both programs rely on a network of occupational physicians. The comparison focuses on data collected in the Centre region and neighboring areas between 2006 and 2008 for Samotrace and in 2008 for MCP. In MCP, work-related mental distress was diagnosed by the occupational physician. In Samotrace, mental distress was assessed using the GHQ28 self-report questionnaire, and the proportion attributable to work was calculated based on program data. Results - The prevalence of work-related mental distress in both programs ranges from 1% to 5%. Among men, both programs agree that the highest prevalences are found among intermediate occupations and clerical workers. Among women, however, an upward gradient from manual workers to managers is observed in MCP, while an inverse gradient—though not statistically significant—is observed in Samotrace. Discussion - This study, which aims to compare two approaches to estimating the prevalence of work-related mental distress, shows a fairly good agreement in the results but also some discrepancies. It demonstrates the need for further research in this area and the value of having multiple data sources. (R.A.)