Sexually transmitted infections (STIs) remain a major public health issue in France. Long-term surveillance is conducted through voluntary networks of clinicians (RésIST) and laboratories (Rénago, Rénachla, and the venereal lymphogranulomatosis network). These networks produce indicators showing trends in the most common bacterial STIs. The number of gonococcal infections increased throughout the decade from 2000 to 2010 in both men and women. The declining susceptibility of gonococcal strains to first-line antibiotics (broad-spectrum cephalosporins) necessitates sustained vigilance. The number of screenings and diagnoses of urogenital chlamydia infections continues to rise in both sexes, particularly due to increased screening among young people. The relative stability of cases of early syphilis and rectal lymphogranuloma venereum (LGV) needs to be confirmed in the coming years. These two STIs predominantly affect gay and bisexual men. There remains a high rate of HIV co-infection with LGV and syphilis, and to a lesser extent with gonorrhea. It is observed that consistent condom use remains insufficient, particularly during oral sex.