Surgical site infections (SSIs), the second most common type of healthcare-associated infection, are associated with longer hospital stays, unplanned reoperations, higher treatment costs, and increased mortality. Since 1999, the ISO-Raisin surveillance system has made it possible to estimate incidence rates for the most common procedures based on specialty and risk factors among patients undergoing surgery. In 2018, 95,388 procedures were reported across 357 healthcare facilities participating in the surveillance program. The crude SSI incidence is estimated at 1.64% [1.55–1.72] and at 0.72% [0.56–0.91] for patients without risk factors. Notable trends over the past five years show an increase in incidence during hip replacement revisions, confirming the rise observed in 2016/2017, and a decrease for abdominal hysterectomies. A national initiative on the surveillance and prevention of infection risks associated with surgical procedures and interventional medicine (SPICMI) will take over from the ISO-Raisin surveillance program starting in 2020. This program will develop a semi-automated collection of ISO events based on routine computerized data collected by the hospital information system.