Objective – The main objective of this observational study, which was conducted in two phases (September 1, 2017 – March 31, 2018, and April 1 – September 1, 2018) was to identify which healthcare professionals screen for and refer patients infected with the hepatitis C virus (HCV) to specialized hepatology clinics. Results – Six hundred ninety-eight patients were included across 38 centers of the ANGH (National Association of Hepatogastroenterologists in General Hospitals). Sixty-two percent were men, with a mean age of 51 years. Patients had advanced chronic liver disease in 32% of cases. Forty percent of this population was considered vulnerable, and 90% of the population was over 40 years old. Screening was performed in 42.3% of cases by a general practitioner, 25% by a specialist or another specialized hospital department, 7.6% by Centers for Addiction Care, Support, and Prevention (CSAPA)/Centers for Reception and Support for Harm Reduction for Drug Users (Caarud), 3.4% in prisons, and 0.7% in psychiatric departments. It was performed due to biological or clinical abnormalities (24%), routinely (27%), or due to the presence of risk factors (36% of cases). Discussion – The general practitioner is the primary actor in screening and referring patients for hepatitis C. Screening is performed due to the presence of risk factors in less than half of cases. Interviewing patients after receiving test results doubles the number of patients identified as having a risk factor. Healthcare professionals’ lack of awareness of risk factors hinders targeted screening. This could be improved by implementing systematic screening at least once in a lifetime for everyone over the age of 40.