As in 2009–2010, all influenza cases admitted to intensive care units during the 2010–2011 winter season were required to be reported to the regional branches of the French Institute for Public Health Surveillance (Cire) using a form that was then entered into a single computer application. A total of 789 cases were reported, the majority linked to the A(H1N1)pdm09 virus, affecting—as during the 2009–2010 pandemic—primarily individuals under 65 years of age (82%) with risk factors (62%). Compared to the pandemic, the overall number of severe cases was observed to have been reduced by half, with a particularly significant decrease in the number of cases among 5- to 14-year-olds and a higher proportion of individuals without risk factors or with obesity who developed acute respiratory distress syndrome or required extracorporeal oxygenation. The case fatality rate was comparable. The 97 cases linked to viruses B and A(H3N2) presented with less severe clinical presentations than those linked to the A(H1N1)pdm09 virus and affected the same proportion of individuals without known risk factors. These characteristics support the strengthening of vaccination and the rapid use of antivirals for at-risk populations, as well as the continued surveillance of severe cases. (R.A.)