Introduction: Cardiovascular diseases (CVD) are the third leading cause of premature death (before age 65) in France. The objective was to examine regional disparities in premature mortality for four of these conditions: ischemic heart disease (IHD), stroke, pulmonary embolism (PE), and heart failure (HF) in 2008–2010, and to examine trends over time between 2000 and 2010. Methods: Data were extracted from the national databases on medical causes of death maintained by the CépiDc. For each condition, regional rates for the 2008–2010 period were standardized to the 2010 European population and then compared to the national rate for 2008–2010, as well as to regional rates for 2000–2002. Results: Significant regional disparities were observed. At the same age structure, the regions of Nord-Pas-de-Calais, Picardy, Upper Normandy, Champagne-Ardenne, Auvergne, and Limousin had higher premature mortality rates than the national rates for these four conditions. In contrast, Île-de-France, Pays-de-la-Loire, Basse-Normandie, Rhône-Alpes, and Midi-Pyrénées had lower rates. Premature mortality from stroke, EP, and HF in the French overseas departments (DOM) was high. Finally, certain regions, such as Alsace, showed highly variable rates depending on the condition. Since 2000–2002, premature mortality has decreased unevenly depending on the region and the condition. Discussion: Despite a significant decrease in premature mortality from CVD over the past decade across all French regions, disparities remain. These are likely linked to variations in the distribution of major risk factors and in clinical management. (R.A.)